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KMID : 0387720190300030241
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Korean Journal of Blood Transfusion
2019 Volume.30 No. 3 p.241 ~ p.245
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A Case of Hemolytic Disease of Newborn due to Anti-Dia: Consideration of the Inclusion of Dia Antigen in Antibody Screening Test
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Kim Han-Sol
Jo Chae-Ku
Kim Sin-Young
Kim Kyeong-Hee
Kim Myo-Jing
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Abstract
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The Diego blood group is expressed as the Dia antigen and Dib antigen, and the frequency of the Dia antigen among the Korean population is estimated to be 9.4~14.5%. We report here on a case of hemolytic disease caused by anti-Dia antibody. A full-term male infant was admitted due to hyperbilirubinemia on the first day of life. The total bilirubin level was decreased after phototherapy, but the hemoglobin level was decreased 6.9 g/dL and an exchange transfusion was then performed. The direct antiglobulin test was strongly positive, but the indirect antiglobulin test using screening blood cells without the Dia antigen was negative. After we suspected neonatal hemolytic disease caused by the anti-Dia antibody, it was confirmed using selected blood cells containing Dia antigen. The newborn and father had DI*A/DI*B and the mother had DI*B. The inclusion of Dia antigens in an unexpected antibody screening test should be actively discussed in Korea.
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KEYWORD
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Hemolytic disease of newborn, Diego, Hyperbilirubinemia
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